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"It is not the strongest of the species that survives, nor the most intelligent that survives. It is the one that is most adaptable to change"   - Charles Darwin

Epigenetic mechanisms act on the regulation of DNA transcription and thus on gene expression regulation, without affecting the DNA sequence itself. Epigenetics is one of the fastest-growing fields for research as well as for Drug Discovery.

The post-translational modifications of Histones (Acetylation, Methylation, as well as Phosphorylation, Ubiquitination, and Citrullination) are the main modifications on Histones. Similar changes on DNA are also involved in these epigenetic phenomena.

To speed up your research concerning these modulations and the numerous interactions leading to gene regulation and phenotypic moderations, we have selected a comprehensive and specialized offer of Epigenetic research tools for you.

Browse through this Epigenetic-focused mini-website, where you'll find all the products and services at your disposal:
  • Ever growing selection of active and highly pure recombinant proteins which cannot be found elsewhere: Various isozymes of HDACs, all 7 Sirtuins (SIRTs), several lysine or arginine methyltransferases as well as DNA methyltransferases and  demethylases.
  • Functional Assay Kits with convenient detection methods (Chemiluminescent, Fluorescence polarization, AlphaLISA)
  • Silenced & ready-to-use cell lines as a model in which a specific epigenetic target is knocked down.
  • Profiling and Screening services (HMT, PARP, PDE, HDAC, DNMT).