Histone Deacetylases

The action of histone deacetylases (HDAC) as well as histone acetylases (HATs) impacts on chromatin folding and condensation which affects gene transcription. Acetylation of histones leads to the opening of the chromatin structure (euchromatin). So the acetylation/deacetylation pair regulates DNA transcription.

Histone deacetylases are involved in removing acetyl groups from an ε-N-acetyl lysine amino acid on a histone.  These "erasers" become the main class of epigenetic proteins that are important targets for Drug Discovery and Research. HDACs inhibitors are potent inducers of growth arrest, differentiation and apoptosis and are used clinically for various diseases. Investigation of new molecules impacting on HDAC activities is still progressing and thus, active HDACs are important tools.

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