Histone acetyltransferases (HATs) allow the acetylation of conserved lysine amino acids on histone proteins. These enzymes transfer an acetyl group from acetyl CoA to form ε-N-acetyl-lysine.

Histone acetylation implies the neutralization of the positive charge normally present on histones surfaces, leading to a reduced affinity between histone and (negatively charged) DNA. By consequence, DNA becomes more accessible to transcription factors, facilitating gene expression.

Browse our ever-increasing list of acetyl transferases

A few active HATs are listed below - click on the table to access full product information





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