Histone Demethylation

Post-translational Histone methylation status is one of the key epigenetic mechanisms. Methylation enzymes pairs involved in Histone modification are being more and more investigated . Two Histone demethylation families have been identified and you'll find below a comprehensive offer of reliable tools to measure their activities or to screen compounds on their activities.

LSD1 functional assays

Lysine specific demethylase 1 (LSD1) is a flavin-dependent monoamine oxidase allowing the demethylation of mono- and di-methylated lysines, (specifically H3K4 and H3K9), but not tri-methylated lysines.

Discover all our luminescent, fluorescent or AlphaLISA Homogenous assay kits

JMJD activity assays

Jumonji domain-containing histone demethylases (JmjC) demethylate mono-, di-, or tri-methylated lysines.

Explore all our luminescent and AlphaLISA JMJD kits

Active Histone demethylases

The singly place to find all demethylase enzymes! Use our powerful web search engine, sorted by protein class.

 

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